Multiple endoscopic pinch biopsy forceps modifications are available, including serrations and fenestrations on the cup and spike to impale the biopsied tissue. Besides the standard biopsy forceps, smaller caliber and large-cup (jumbo) biopsy forceps are available. Special miniature forceps for passage through a cholangioscope and even a 19G fine needle aspiration (FNA) device is commercially available. Besides advancements in brushing cytology from the biliary tract, newer cytology acquisition devices are being developed for a wide-field sampling of Barrett’s epithelium (BE) for screening and surveillance. Endoscopic ultrasound (EUS) fine needle aspiration and biopsy (FNA and FNB) devices are also discussed with practical advice on processing the acquired cytology, cell-block, cyst fluid, and microcores in the endoscopy suite before submission.