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Clinical Profile and Survival of Patients with Carcinoma Gall Bladder: A Retrospective Study of 1002 Patients from Eastern India
Manas Kumar Behera1, Debakanta Mishra2, Shobhit Agarwal2, Jimmy Narayan2, Manoj Kumar Sahu2, Satya Sundar Gajendra Mohapatra3, Priyam Agarwal3, Ayaskanta Singh2, Girish Kumar Pati2
1Department of Hepatology, S.C.B. Medical College and Hospital,Cuttack, India; 2Department of Medical Gastroenterology, Institute of Medical Sciences & SUM Hospital, Bhubaneswar, India; 3Department of Radiodiagnosis, Institute of Medical Sciences & SUM Hospital, Bhubaneswar, India.

Corresponding Author
Dr. Shobhit Agarwal


Background: Gall blabber cancer (GBC) is one of the most prevalent gastrointestinal cancer in India, seen more in the north and central India. However, the data from eastern India is scanty, especially from state of Odisha, where there is recent surge in numbers of GBC. 
Methods: A retrospective study was conducted after reviewing hospital records over a period of 7 years from 2012 to 2018. A total 1002 GBC patients were examined for clinical features, histological grade, and survival as per stage of the disease. 
Result: Median age of patients was 55 years and with male: female ratio of 1:2.2. Total number of GBC cases were steadily increasing every year from 2012(80) to 2018 (204). Around 95 % GBC patients were of stage III and stage IV disease. Most common symptom was pain abdomen (85%) followed by jaundice (72%) and pruritus (54%). Cholelithiasis was noted in 387 (39%) patients. Most common radiological finding was mass replacing GB fossa in 645 (64%). Adenocarcinoma was the most common histologic subtype of GBC in 86% cases. Liver was most common site of metastasis (44%) followed by peritoneum (24%), lungs (13%), and bones (3%). Adrenal metastasis, which is a rare finding in GBC, was found in 2% patients. The median survival for stage I, II, III and IV diseases was 44, 38, 26 and 5.3 months respectively. 
Conclusion: The incidence of GBC is alarming in the state of Odisha and most patients presented in stage IV disease with median survival of less than 6 months. Adrenal metastasis although rare occurrence in GBC, was found in 2% patients.