Sitemap | Policies | Feedback    
 About the Journal
Editorial Board
Journal Subscription
Instructions for Authors
E-mail Alerts
Forthcoming Events
Advertise with Us
Contact Us
Article Options
Printer Friendly Version
Search Pubmed for
Search Google Scholar for
Article Statistics
Bookmark and Share
Seroprevalence of Hepatitis C Virus in Liver Disease Patients and Blood Donors from Northern India
Deepak Kumar1, Jayanta Borkakoti2, Harimohan3, Rahul Karna2, Premashis Kar2
1Department of Biotechnology and Molecular Medicine, Pt. B. D. Sharma Postgraduate Institute of Medical Sciences, Rohtak; 2Department of Medicine, Maulana Azad Medical College, University of Delhi, Delhi; 3Centre for Medical Biotechnology, Maharshi Dayanand University, Rohtak.

Corresponding Author
Dr Premashis Kar


Background: The molecular epidemiology of HCV and its association with liver diseases in North India is not well understood. 
Aim: To assess the incidence of HCV infection in blood donors and liver disease patients and the influence of HCV genotype on the severity of the liver disease.
Methods: We screened 487 patients with acute viral hepatitis (AVH), 141 patients of fulminant hepatic failure(FHF), 1058 patients of chronic liver disease (CLD) (chronic hepatitis-468, cirrhosis-527, HCC-63), and 3504 voluntary blood donors for anti-HCV. Anti HCV positive patients were further subjected to HCV RNA testing followed by genotyping.
Results: HCV infection was observed in 1.6%, 12.94%, 10.64%, 27.13%, 21.25% and 49.2% of blood donors, AVH,FHF, chronic hepatitis, cirrhosis and HCC patients respectively. 
Conclusion: Genotype 3 was found to be the major genotype. HCV genotype one infection was associated with advanced liver disease.