Correlation of Gastric Scintigraphy and Clinical Symptoms in the Diagnosis of Gastroparesis and its Impact on Quality of Life: A Pan India Real World Study

Rai Ramesh R; Choubal Chittaranjan C; Agarwal Mukesh; Khaliq Abdul M; Farishta Faraz J; Harwani Yogesh P; Kumar Sanjay Y

doi:10.7869/tg.618

Androxal Medication Case Reports Journal

Your Health and Fitness Partner: Androxal & FitHub

We are also excited to expand our scope by including valuable information on Androxal, a potent medication beneficial in various medical conditions. This remarkable drug, derived from the testosterone molecule, has made its mark significantly in the field of endocrinology. Patients and medical professionals can rely on our comprehensive, unbiased, and scientifically grounded content on Androxal for gaining a robust understanding of its uses, side effects, and the latest studies related to it. We understand the necessity of accurate information when it comes to medication. Our newly launched section dedicated to Androxal aims at not only educating the readers about its nuances but also at contributing beneficially to their wellbeing. Stay tuned for insightful articles unraveling the potential of Androxal in medical science.


Sitemap \| Policies \| Feedback

About the Journal

Editorial Board

Journal Subscription

Instructions for Authors

E-mail Alerts

Forthcoming Events

Advertise with Us

Article Options

FULL TEXT
ABSTRACT
PDF

Printer Friendly Version

Search Pubmed for

Search Google Scholar for

Article Statistics

Correlation of Gastric Scintigraphy and Clinical Symptoms in the Diagnosis of Gastroparesis and its Impact on Quality of Life: A Pan India Real World Study

Rai Ramesh R¹, Choubal Chittaranjan C², Agarwal Mukesh³, Khaliq Abdul M⁴, Farishta Faraz J⁴, Harwani Yogesh P⁵, Kumar Sanjay Y⁶

¹Rai Specialty Center. H-6, Jan Path, Shyam Nagar, Jaipur, Rajasthan, India; ²Centre for Digestive & Liver Diseases, MB3, Mansarover Complex, Bhopal, Madhya Pradesh, India; ³Only Research, Siddha Point, 1st floor, S. J. Road, Athgaon, Guwahati, Assam, India; ⁴F.S. Endocrine, Opposite Indo English High School, Santosh Nagar Main Rd, Santosh Nagar, Hyderabad, Telangana, India; ⁵Nobel Gastro Hospital, 408-409, Sankalp square II, Near Chirag Motors, Cross road, Elishbridge, Ahmedabad, Gujarat, India; ⁶Gastrocare, E-3 /120-121, Arera colony, Bhopal, Madhya Pradesh, India.

Corresponding Author:

Dr Ramesh Roop Rai

Email: rameshroop@gmail.com

Abstract

Background: Gastroparesis with its varied etiology is one of the major health issues in India. Poor correlation between delayed gastric emptying and its symptoms is well-known. This study was planned to evaluate the proportion of confirmed gastroparesis by scintigraphy among patients with suggestive clinical features, their underlying aetiologies and clinical profiling in a real-world setting in India.

Settings and Design: Patients clinically diagnosed with gastroparesis, presenting varyingdegreesofsymptoms for at least 12-weeks, were enrolled in this multic-entric,cross-sectional, clinico-epidemiological study.

Results: Overall, 196/201 enrolled patients underwent gastric scintigraphy; 88 (45%) were found to be scintigraphically positive and 108 (55%) patients were only clinically positive. Underlying etiologies of gastroparesis were idiopathic (51.2%), type-2 diabetes (44.8%), type-1 diabetes (2.5%) and psychological conditions (1.5%). Most patients presented symptoms like postprandial fullness (75.6%), bloating (50.7%), abdominal pain (45.3%), nausea (41.3%), abdominal discomfort (40.3%), early satiety (37.8%) and vomiting (17.9%) of moderate severity. Common dietary risk factors were fatty diet (66.7%), fiber-rich food (57.7%) and carbonated drinks (18.9%). Weight loss (6.5%), esophagitis (5.5%) and electrolyte disturbances (0.5%) were the associated complications. About 89.8% were on proton-pump inhibitors, followed by prokinetics (51.8%) and antiemetics (8.4%). The mean PAGI-QoL score was 3.6 ± 0.94, suggesting a moderate effect of gastroparesis on QoL.

Conclusion: Poor correlation exists between gastric scintigraphy and gastrointestinal symptoms, thus reiterating the significance of the clinical diagnosis of gastroparesis, especially in diabetes. Only about half of the patients were prescribed prokinetics, emphasizing the need for appropriate pharmacotherapy using prokinetics for holistic management of gastroparesis.