Helicobacter pylori Antigen Recognition Patterns Among Cuban Patients Using Helicoblot 2.1 Diagnostic System

Onelkis Feliciano; Rosabel Falcon; Amilcar Duquesne; Osmel Fleitas; Tatiana Almaguer; Oderay Gutierrez; Armando Orellana; Virginia Capo; Rafael Llanes

doi:10.7869/tg.541

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Helicobacter pylori Antigen Recognition Patterns Among Cuban Patients Using Helicoblot 2.1 Diagnostic System

Onelkis Feliciano¹, Rosabel Falcon¹, Amilcar Duquesne², Osmel Fleitas¹, Tatiana Almaguer¹, Oderay Gutierrez¹, Armando Orellana³, Virginia Capo⁴, Rafael Llanes¹

¹Center for Research, Diagnostic and Reference, “Pedro Kouri” Tropical Medicine Institute (IPK), Havana, Cuba. ²Microbiology Department, Fructuoso Rodriguez Hospital, Havana; Cuba. ³Endoscopy Department. Primary Healthcare Institution ¨19 de abril¨, Havana, Cuba. ⁴Histopathological Department, IPK, Havana, Cuba.

Corresponding Author:

MSc. Onelkis Feliciano

Email: onelkisfs@infomed.sld.cu.

Abstract

Background: Helicobacter pylori infection is associated with the development of gastroduodenal diseases. Aim: This study was planned to assess the relationship between H. pylori-infection and bacterial antigen recognition in Cuban patients.

Methods: One hundred-five subjects (7-82 years old) with gastroduodenal symptoms were enrolled. Collected sera were evaluated by Helicoblot 2.1 and the antigen seroprevalence growth by age decade was calculated.

Results: Sixty-one (58.1%) subjects were considered infected with H. pylori by biopsy. The accuracy of Helicoblot 2.1 showed good sensitivity and specificity. VacA antigen seroreactivity was found to be significantly high in infected patients (P=0.00). The number of recognized proteins in H. pylori-infected patients from 40-61 years old was 2.5-fold superior compared to the youngest (5-17 years old) (P=0.04). Intestinal metaplasia and dysplasia were highly prevalent in the 40-50 age group.

Conclusion: VacA protein can be considered a marker of H.pylori infection in Cuban population. In addition, a high frequency of premalignant lesions associated to H. pylori infection was observed in this study to suggest the establishment of early Cuban surveillance strategies.