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Atrophic gastritis with high prevalence of Helicobacter pylori is a predominant feature in patients with dyspepsia in a high altitude area
 
Piyush Kumar Sharma,1 Tejas Menon Suri,1 Pratap Mouli Venigalla,1 Sushil Kumar Garg,1 Ghulam Mohammad,2 Prasenjit Das,3 Seema Sood,4 Anoop Saraya,1 Vineet Ahuja1
Departments of Gastroenterology
and Human Nutrition,1
Pathology,3 and Microbiology,4
All India Institute of Medical
Sciences, New Delhi.
Department of Medicine,2
Sonam Norboo Memorial
Government Hospital,
Leh, Ladakh,
Jammu and Kashmir, India.


Corresponding Author: Dr. Vineet Ahuja
Email: vins_ahuja@hotmail.com

Abstract

Background: Dyspepsia is a common symptom in residents of Leh, a high-altitude region in Ladakh, India. Helicobacter pylori related gastritis is a common cause of such symptoms. However data regarding this association at high altitudes is sparse.

Aim: To investigate the demographic, endoscopic and histopathology findings in patients presenting with dyspeptic symptoms in the high-altitude region of Leh. Methods: A crosssectional study was done in 84 patients with dyspeptic symptoms, attending the outpatient department of local government hospital in Leh. Demographic details, endoscopy, histopathology of upper gastrointestinal biopsies and microbiology culture of gastric/duodenal aspirates were studied.

Results: The mean age was 38.4 years with 42% being males. Indigenous foods with high-salt content were consumed by 75% of patients. Epigastric pain was the most frequent symptom (in 96%) and pain radiating to the back was another peculiar symptom seen in 49% of patients. The predominant finding on endoscopy was antral gastritis in 71% of patients. Nodular gastritis was seen in 18% of patients. H. pylori was documented in 93% and histopathology revealed mild-to-moderate inflammation in 93% and mild-to-moderate atrophy in 90% of patients. Colonization with Gram-negative bacilli was observed in gastric/duodenal aspirate cultures.

Conclusion: Dyspepsia at high-altitude commonly presents as pain radiating to the back with a very high (90%) prevalence of H. pylori, endoscopic findings of antral gastritis and nodular gastritis, and atrophic gastritis in biopsies. Further investigations are needed to determine whether these observations are related to the high-altitude or the high-salt content in their diet and also whether these further translate to carcinogenesis.

© 2008 Tropical Gastroenterology
ISSN: Print - 0250-636X